Jakki Cooney Dr. Department of Life Sciences, Materials and Surface Science Institute, University of Limerick, Plassey, … 29 Aug My work extends into the pre-formulation space of active pharmaceutical ingredients by controlled crystallisation of the optimal solid form, be it a crystal, co-crystal or salt, in the absence or presence of an excipient, such that process ability, stability and drug efficacy in vivo may be enhanced. I would like to thank my supervisor Dr Sarah Hudson for her support and guidance throughout this project. We examine the factors that influence the optimisation of mammalian and microbial fermentation processes for the production of small and large molecules. sarah.hudson@ul.ie Keywords: Mesoporous matrices; Nisin A; Controlled release; Antimicrobial; periodic mesoporous organosilanes; simulated gastrointestinal fluid; bacteriocins Abstract Mesoporous matrices of different pore size and chemical composition were explored as potential delivery matrices for the broad spectrum bacteriocin, nisin A. Bernal Recruitment The Bernal Institute creates an excellent doctoral training environment, and overall a conducive mentoring environment that attracts top class graduate students and postdocs to our research clusters. Researchers from around Ireland gathered in University of Limerick (UL) on Friday morning to listen to one of the world’s top engineers discuss his work in the area of biomaterials and biotechnology. Angewandte Chemie International Edition 47 (45), 8582-8594 Master’s Thesis . OVERALL PURPOSE OF THE JOB: To establish processes and procedures that will develop the SFI funded Bernal BioLabs BioProcess infrastructure testbed into a self-sustainable facility with independent projects, future proofing the operation of the facility and the translation of research between academia and industry and to engage in the development of methods and knowledge on This cookie is strictly necessary for Cloudflare's security features and cannot be turned off. Using crystallisation approaches or delivery matrices (polymeric or ceramic), we seek to maximise the bioavailability and activity of these molecules in vivo and reduce the cost of their development into medicines. b Bernal Institute, School of Engineering, University of Limerick, Co., Limerick, Ireland Abstract. She completed her PhD with Prof Edmond Magner, Prof Kieran Hodnett and Dr Jakki Cooney in the immobilisation of enzymes at the University of Limerick. Home » Uncategorized » sarah hudson ul . PMID: 30579056 DOI: 10.1016/j.colsurfb.2018.12.021 Abstract Drug nanoparticles are a promising solution to the challenging issues of low dissolution rates and erratic bioavailability due to their greater surface/volume ratio. Proteins in mesoporous silicates S Hudson, J Cooney, E Magner Sarah Hudson UL sarah.hudson@ul.ie Sarah Hayes UL sarah.hayes@ul.ie Marie Walsh LIT marie.walsh@lit.ie Anne O’Dwyer UL anne.m.odwyer@ul.ie Muireann Sheehan UL muireann.sheehan@ul.ie Maria Sheehan maria.sheehan@ul.ie Aine Regan aine.regan@ul.ie Marie Ryan UL marie.c.ryan@ul.ie Lisa Gibbons UL lisa.gibbons@ul.ie Sarah Hudson Dr. E-mail address: sarah.hudson@ul.ie. Department of Chemical and Environmental Sciences, Materials and Surface Science Institute, University of Limerick, Plassey, Co. Electron microscopy. Anke Prudic-Paus (Janssen) Read More » Supervisors. I declare that this thesis is entirely my own work and has not been previously submitted to this or any other university. We functionalise materials to tailor the immobilisation of enzymes to generate biocatalysts with optimal activity and stability. Bacteriocins, which are antimicrobial peptides, are a potential alternative to current ineffective antimicrobial therapies. UL will receive close to €2m in research funding under the programme for four projects based at the University. Ireland . Their research focuses on the thermodynamics behind aggregation, crystallisation and precipitation in a range of solvents and bio relevant media and develops formulations to control this solution/solid-state behaviour. She is the project coordinator for LongActNow and project leader on a Disruptive Technology Innovation Award on the development of enzymes as therapeutics. We study the effects of the components bio-relevant media on the solution and crystallisation behaviour of active pharmaceutical ingredients in vitro – quantifying drug-component interactions and their influence on nucleation and crystallisation events. michael.h.hayes@ Sarah graduated from Trinity College Dublin in 1999 as a Trinity Foundation Scholar. (Read more. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 861278. Adjunct Prof. Chemistry of the Colloids in Soils and Waters. One main target application is in the formulation of new drugs to treat antimicrobial resistant infections. This research will develop biocatalysts using immobilised enzymes for synthetic and medical applications. Sarah is a Materials theme leader and funded investigator in the SSPC. The biocompatibility (in vivo and in vitro) of micro- and nano- mesoporous silica particles was also studied. Qualifications. Sarah Hudson is currently signed to Prescription Songs/AAM as a songwriter. Work location(s) 2 position(s) available at. Submitted to the University of Limerick, April 2017 . Other research interests include bioprocessing, biocatalysis and drug delivery. Limerick V94 T9PX. Project Details. Sarah Hudson (UL) Read More » Supervisors. ii Acknowledgements . Nucleation and particle growth, release kinetics, bioavailability. Co. She is a funded investigator in the Synthesis and Solid State Pharmaceutical Research Centre (SSPC) since 2013. In both of these research strands, the following analytical techniques are heavily relied upon: Solid state NMR, X-ray diffraction Jakki Cooney Dr. Department of Life Sciences, Materials and Surface Science Institute, University of Limerick, Plassey, Co. I was also responsible for the installation and use of a solid state NMR system. by research in Chemistry, Trinity College Dublin. Electronic address: Sarah.Hudson@ul.ie. Electronic address: Sarah.Hudson@ul.ie. Since November 2011, I have been a lecturer in Chemistry in the Department of Chemical Sciences and a researcher in the Bernal Institute in the University of Limerick. Prof. Michael HB Hayes. CONTACT. SSPC University of Limerick Bernal Institute Castletroy. See the complete profile on LinkedIn and discover Sarah’s connections and jobs at similar companies. The Journal of Physical Chemistry B 109 (41), 19496-19506 _____ Sarah Mallen . Biomaterials 29 (30), 4045-4055 University of Limerick . Yina Guo Researcher, University of Limerick Verified email at ul.ie. Search for more papers by this author. We track anonymized user information to improve our website. (Mod) in Chemistry, Trinity College Dublin. Dr Sarah Hudson, Department of Chemical Sciences, Bernal Insitute, University of Limerick. • View Journal Article, Methodology for the immobilization of enzymes onto mesoporous materials David Murray. Electronic address: Sarah.Hudson@ul.ie. View Sarah Hudson’s profile on LinkedIn, the world’s largest professional community. by research in Chemistry, Trinity College Dublin. I would also like to thank the other members of our research group, Edel and James, for making UL an enjoyable place to be. Gabriele Sadowski (TUD), Sarah Hudson (UL), Philippe Fernandes (Janssen) Eligibility Criteria: MSc in chemical engineering or physical chemistry; Applicants must not have resided or carried out their main activity in Germany for more than 12 months in the 3 years immediately before the date of application. I will be forever grateful for all her help, anything I achieve will be thanks to the mentoring I received from you during the last four years. I then secured a Marie Curie Fellowship with Prof Robert Langer in MIT, USA where I worked on the development of in situ crosslinkable hydrogel systems for cartilage regeneration and drug delivery. Submicron to small-micron-sized particles of the hydrophobic drug, fenofibrate, were prepared by controlled crystallization in order to influence its dissolution behavior. This work focuses on the improvement of drug bioavailablilty by crystal engineering approaches, by using ceramics and synthetic polymers as delivery vehicles and by exercising control over crystal growth of sub-micron nanocrystals of poorly water soluble drugs. Pictured with MIT’s Professor Robert Langer on his recent visit to UL to deliver the second in the Bernal Distinguished Lecture Series, is Dr Sarah Hudson. In order to use this website we use the following technically required cookies. V94 T9PX . Research and Teaching Interests. The awardees are Bernal Institute Members and SSPC Researchers, Dr Sarah Hudson and Dr Luis Padrela, UL Chair of Mechanical Engineering, Professor Noel O’Dowd, and Dr Norma Bargary of UL’s Department of Mathematics and Statistics, who will … For perfomance reasons we use Cloudflare as a CDN network. She was awarded a masters in Chemistry from Trinity a year later, where she worked on the photophysical properties of rhenium complexes with Prof John Kelly. Start Date: March 2020. Dr Sarah Hudson, Department of Chemical Sciences, Bernal Insitute, University of Limerick Sarah graduated from Trinity College Dublin in 1999 as a Trinity Foundation Scholar. Sarah has 4 jobs listed on their profile. When you visit any web site, it may store or retrieve information on your browser, mostly in the form of cookies. i Declaration . After this fellowship, I worked in Waterford Institute of Technology on the identification of the mechanisms and causes of tablet splitting within the Genzyme Ireland Ltd. facility. • View Journal Article, Dairy Processing Technology Centre | DPTC, Pharmaceutical Manufacturing Technology Centre | PMTC, SSPC, the SFI Research Centre for Pharmaceuticals. PMID: 27884714 DOI: 10.1016/j.ijpharm.2016.11.045 Abstract Nanoparticles of poorly water-soluble drugs were prepared in suspension via antisolvent precipitation in order to improve their dissolution behaviour. L. monocytogenes infections can cause life-long effects in the elderly a … B.A. MSSI Building, Specialist Diploma in Teaching, Learning and Scholarship, Ph.D. Chemistry University of Limerick. J. Gerard Wall NUI Galway … A song she co-wrote with Katy Perry, Dr. Luke, Max Martin and Cirkut entitled "Dark Horse" became Perry's third single off her album, Prism. She currently supervises 8 PhD students, 4 postdoctoral researchers and 2 research assistants. E-mail: sarah.hudson@ul.ie. Thermal analysis (TGA, DSC) S Hudson, E Magner, J Cooney, BK Hodnett B.A. Open, Transparent, Merit based Recruitment procedures of Researchers (OTM-R) Know more about it at … Sarah Hudson Dr. sarah.hudson@ul.ie; Department of Chemical and Environmental Sciences, Materials and Surface Science Institute, University of Limerick, Plassey, Co. HPLC, UV-vis and FTIR 4 Synthesis and Solid State Pharmaceutical Centre, Department of Chemical Sciences, The Bernal Institute, University of Limerick, Limerick, V94 T9PX, Ireland. Closing Date: 17:00 Friday, 14-May-2021 Position: By agreeing you accept the use of cookies in accordance with our cookie policy. Since November 2011, Sarah has been a lecturer in Chemistry in the Department of Chemical Sciences and a researcher in the Bernal Institute in the University of Limerick. View Map (+353) 061 233754 (+353) 061 234675 These cookies allow us to count visits and traffic sources, so we can measure and improve the performance of our site. • View Journal Article, The biocompatibility of mesoporous silicates (Mod) in Chemistry, Trinity College Dublin. Email: tewfik.soulimane@ul.ie (T. S.) and Email: sarah.hudson@ul.ie (S. P. H.) Search for more papers by this author. Office: MS2-019, These cookies are necessary for the website to function and cannot be switched off in our systems. An antisolvent precipitation process successfully generated particles (200–300 nm) which matched the size and dissolution behavior of a commercial wet-milled formulation of the drug. sarah.hudson@ul.ie . University of Limerick. The Hudson research group focuses on the manipulation of the physicochemical properties of small and large active molecules to improve their stability, solubility and dissolution rates with the ultimate goal of improving the bioavailability of active pharmaceutical ingredients. Qualified PRINCE2 Practitioner in project management. Sarah HUDSON, Senior Lecturer | Cited by 2,022 | of University of Limerick (UL) | Read 63 publications | Contact Sarah HUDSON Limerick . Limerick . Following a sabbatical from academia spent working as a raft guide and safety kayaker on 3 continents, I completed my PhD in 2006 on the immobilization of enzymes onto novel mesoporous supports and their catalytic properties in the University of Limerick. *Corresponding author: Sarah.Hudson@ul.ie 10 Abstract Nanoparticles of poorly water-soluble drugs were prepared in suspension via antisolvent precipitation in order to improve their dissolution behaviour. Her subsequent postdoctoral studies were spent with Prof Robert Langer at Massachusetts Institute of Technology in Boston and Dr Peter McLoughlin at Waterford Institute of Technology, Ireland where she moved into the field of drug delivery and pharmaceutical manufacturing. Project Details. "Dark Horse" has been a commercial success, charting at number one on the US Billboard Hot 100. Biography Sarah studied Chemistry in Trinity College Dublin were she was a Trinity Foundation Scholar and where she did a research masters on the synthesis of a family of Re (I) metal complexes and a study of their photophysical properties with Prof John Kelly. We prioritise talent development to support our people to become national and global influencers in their field. Limerick IE (Ireland), Fax: (+353) 61‐213‐529. Search for more papers by this author. See more of Sarah Hudson - Liberty on Facebook. I studied Chemistry in Trinity College Dublin which led to a research masters on the synthesis of a family of Re (I) metal complexes and a study of their photophysical properties. Our Early Stage Researchers & Supervisors. They explore the solution and solid-state behaviour of these molecules both during formulation/manufacture into medicines and in biorelevant environments. My research is divided into two main strands: Drug formulation and delivery Deadline for applications is 15 June 2020, 5pm (Irish Standard Time). My research focuses on the control of nucleation of organic pharmaceutical molecules and the development of crystallisation technologies to improve the bioavailability of such molecules. Specialist Diploma in Teaching, Learning and Scholarship, Ph.D. Chemistry University of Limerick. 137 Co-reductive fabrication of carbon nanodots with high quantum yield for bioimaging of bacteria Jiajun€Wang1, Xia€Liu1, Gesmi€Milcovich2, Tzu-Yu€Chen3, Edel€Durack2, Sarah€Mallen2, Yongming€Ruan1, Xuexiang€Weng*1 and€Sarah€P.€Hudson*2 Full Research … We use cookies to give you the best online experience. Lacticin 3147 is a dual-acting two-peptide bacteriocin which is generally active against Gram-positive bacteria, including Listeria monocytogenes and antimicrobial-resistant bacteria such as Closteroides difficile in the colon. Limerick . Biocatalysis Miriama Ceresnakova. Search for more papers by this author. She was awarded a masters in Chemistry from Trinity a year later, where she worked on the photophysical properties of rhenium complexes with Prof John Kelly. SP Hudson, RF Padera, R Langer, DS Kohane Informal queries can be sent to Sarah.Hudson@ul.ie or gabriele.sadowski@tu-dortmund.de. Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland. Rene Holm (Janssen), Sarah Hudson (UL), Lidia Tajber (TCD) Eligibility Criteria: Minimum BSc in chemical engineering, physical chemistry or related discipline; Applicants must not have resided or carried out their main activity in Belgium for more than 12 months in the 3 years immediately before the date of application. COOK Ireland Limited, Limerick, Ireland . Supervisor: Dr. Sarah Hudson . `` __cfduid '' to apply sarah hudson ul settings on a Disruptive Technology Innovation Award on the US Hot. Activity and stability your browser, mostly in the SSPC Hot 100 Cloudflare as a Trinity Scholar... 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